University of Sussex
Dr Leandro Castellano is Senior Lecturer in Biochemistry at the University of Sussex in Brighton, and honorary Senior Lecturer at Imperial College London (UK). He obtained a PhD in 2007 at the University “La Sapienza”, Rome, working on the role of microRNAs in solid and liquid cancers. He then moved to Imperial College the same year where he identified for the first time that microRNAs can be regulated by oestrogen receptor alpha (ER-alpha) in ER positive breast cancer which in turn, modulate ER-alpha itself. This regulative miRNA-mRNA network forms a negative feedback loop crucial for breast cancer progression. His research interest focuses on the role of short and long non-coding RNAs in the progression of breast, pancreatic and other solid cancers. He published several articles reporting finding on the role of non-coding RNAs in these diseases using high-throughput sequencing technologies for global discoveries.
Solid cancer, non-coding RNA, gene expression, biological networks in cancer